Waynesville is a village in DeWitt County, Illinois, United States. The population was 381 at the 2020 census. Waynesville is one of the oldest settlements in central Illinois. The area was first settled around 1825, by Prettyman Marvel and his wife, Rebecca Marvel. They cleared an area of land near the present location of the village and were followed shortl…Waynesville is a village in DeWitt County, Illinois, United States. The population was 381 at the 2020 census. Waynesville is one of the oldest settlements in central Illinois. The area was first settled around 1825, by Prettyman Marvel and his wife, Rebecca Marvel. They cleared an area of land near the present location of the village and were followed shortly thereafter by several other settlers. As a result, a small settlement sprung up about a mile south of Kickapoo Creek.
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